Are caveolin-1 minor alleles more likely to be risk alleles in insulin resistance mechanisms in metabolic diseases?
نویسندگان
چکیده
منابع مشابه
Derived SNP Alleles are Used More Frequently than Ancestral Alleles as Risk-associated Variants in Common Human Diseases
Evolutionary aspects of the genetic architecture of common human diseases remain enigmatic. The results of more than 200 genome-wide association studies published to date were compiled in a catalog (). We used cataloged data to determine whether derived (mutant) alleles are associated with higher risk of human disease more frequently than ancestral alleles. We placed all allelic variants into t...
متن کاملAPOL1 Risk Alleles Are Associated With More Severe Arteriosclerosis in Renal Resistance Vessels With Aging and Hypertension
The increased risk of end-stage kidney disease (ESKD) among hypertensive African Americans is partly related to APOL1 allele variants. Hypertension-associated arterionephrosclerosis consists of arteriosclerosis, glomerulosclerosis, and cortical fibrosis. The initial glomerulosclerosis, attributed to preglomerular arteriosclerosis and ischemia, consists of focal global glomerulosclerosis (FGGS),...
متن کاملShould kidney donors be genotyped for APOL1 risk alleles?
Clinical nephrology has advanced rapidly due to recent breakthroughs in genomic medicine. Several forms of nephropathy heretofore labeled “idiopathic” now have a well-defined genetic basis; more will follow. Whereas it was once taboo to suggest that population ancestry-based genetic variation contributes to ethnic-specific risk for end-stage kidney disease (ESKD), the identification of impressi...
متن کاملAre specimens with "at risk" biochemical profiles more likely to be infectious for hepatitis B virus?
The potential infectivity of 640 plasma specimens with various biochemical profiles was directly assessed by hepatitis B virus (HBV) DNA dot-hybridization. We found that specimens with "at risk" biochemical profiles typical of various forms of liver disease were not significantly more likely to carry HBV than the general patient population. Specimens containing HBV cannot be distinguished from ...
متن کاملAccumulation of Minor Alleles of Common SNPs in Schizophrenia
Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. A number of large scale genome wide association studies have identified numerous individual risk single nucleotide polymorphisms (SNPs) whose precise roles in schizophrenia remain unknown. Accumulation of many of these risk alleles has been found to be a more important risk factor. Consistently, recent studies showe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2021
ISSN: 1756-0500
DOI: 10.1186/s13104-021-05597-6